Category: PCT

Porphyria cutanea tarda and diabetes mellitus

A PubMed study by Muñoz-Santos C1, Guilabert A, Moreno N, Gimenez M, Darwich E, To-Figueras J, Herrero C.

Abstract

An association between porphyria cutanea tarda (PCT) and diabetes mellitus (DM) is widely reported, but the pathogenetic link remains unknown. This retrospective longitudinal study included 81 Spanish patients with PCT with at least 10 years of strict follow-up. Patients attended our Porphyria Unit for follow-up visits and the data were collected in the period 2004-2008. We classified patients into two groups: patients with glucose metabolism alterations (GMA: DM or impaired fasting glucose), and patients without. PCT features and PCT and DM risk factors were retrieved from clinical charts and compared between groups.
GMA are highly prevalent in patients with PCT and mostly develop a long time after the diagnosis of PCT. Persistent hyperferritinaemia seems to be a risk biomarker of GMA in patients with PCT, probably in the setting of chronic iron overload and hepatic inflammation. Strict long-term monitoring of glucose metabolism and serum ferritin may be advisable in the routine follow-up of patients with PCT.
PMID:21564073 DOI:10.1111/j.1365-2133.2011.10401.x   – © 2011 The Authors. BJD © 2011 British Association of Dermatologists.